20 -11 (85) 2025 - O.G.Aslanov, R.R.Baymuradov - HISTOMORPHOMETRIC AND MICROCIRCULATORY CHANGES IN THE THYROID GLAND OF WHITE OUTBRED RATS WITH MICROELEMENT DEFICIENCY
- O.G.Aslanov - Bukhara State Medical Institute named after Abu Ali ibn Sina
- R.R.Baymuradov - Bukhara State Medical Institute named after Abu Ali ibn Sina
Resume: This study investigates histomorphometric and microcirculatory changes in the thyroid gland of white laboratory rats under magnesium, iron, selenium, and zinc deficiency. Morphometric analysis revealed a decrease in gland mass, follicular and capillary diameters, and an increase in intervascular distance and stromal proportion. The most pronounced changes were observed under magnesium deficiency. The findings confirm the crucial role of trace element balance in maintaining the morphological integrity and functional stability of the endocrine system.
Key words: Keywords: trace elements, thyroid gland, magnesium, selenium, zinc, iron, histomorphometry, experimental study, microcirculation.
Pages: 106–110
For citation:
O.G.Aslanov, R.R.Baymuradov - HISTOMORPHOMETRIC AND MICROCIRCULATORY CHANGES IN THE THYROID GLAND OF WHITE OUTBRED RATS WITH MICROELEMENT DEFICIENCY//New Day in Medicine 11(85)2025 106-110 https://newdayworldmedicine3d.com/en/new_day_medicine/11-85-2025
List of References
- Altura B.M., Gebrewold A. Magnesium deficiency and endothelial dysfunction // Magnesium Research. 2018;31(3):85-92.
- Beard J.L., Dawson H., Piñeiro-Carrero V. Iron deficiency and thyroid hormone metabolism // Biological Trace Element Research. 2020;195(2):414-421.
- Köhrle J., Baeuerlein R. Zinc and thyroid: regulatory interactions // Journal of Trace Elements in Medicine and Biology. 2017;43:45-52.
- Kulikova O.V., Medvedeva N.V., Sokolov V.A. Environmental trace elements imbalance and thyroid pathology risk // Human Ecology. 2021;28(4):63-70.
- Schomburg L. Selenium, selenoproteins, and thyroid hormone metabolism // Nutrients. 2022;14(3):531-540.
- Zhang L., Sun J., Liu Y., et al. Morphological changes of thyroid microvasculature under magnesium deficiency in laboratory rats // International Journal of Experimental Pathology. 2018;99(4):215-223.
- Zimmermann M.B. Thyroid physiology and disorders in relation to nutrition and environment // Endocrine Reviews. 2019;40(5):1008-1049