13 -12 (86) 2025 - Kholov Kh.N. - FEATURES OF THE CLINICAL COURSE OF CHRONIC PURULENT RHINOSINUSITIS IN COMBINATION WITH METABOLIC SYNDROME

Resume: The purpose of this study was to study the relationship between the immune profile and the metabolic syndrome in patients with chronic purulent rhinosinusitis. A comprehensive analysis of clinical, immunological and biochemical parameters was performed in patients suffering from chronic inflammation of the paranasal sinuses, accompanied by purulent secretion. The levels of pro-inflammatory and anti-inflammatory cytokines, immunoglobulins of various classes, as well as parameters of metabolic metabolism, including lipid and carbohydrate spectra, were studied. It was found that patients with a combination of chronic rhinosinusitis and metabolic syndrome have a pronounced imbalance of the immune response, manifested by an increase in the concentration of IL-6, TNF-α, IgE and a decrease in the level of IL-10, which correlates with the severity of the clinical course of the disease. The data obtained confirm the existence of a close relationship between metabolic disorders and changes in the body's immune reactivity, which determines the need for an integrated approach to the diagnosis and treatment of such patients.

Key words: Key words: chronic purulent rhinosinusitis, cytokines, metabolic syndrome.

Pages: 64–72

For citation:

Kholov Kh.N. - FEATURES OF THE CLINICAL COURSE OF CHRONIC PURULENT RHINOSINUSITIS IN COMBINATION WITH METABOLIC SYNDROME//New Day in Medicine 12(86)2025 64-72 https://newdayworldmedicine3d.com/en/new_day_medicine/12-86-2025

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