77 -12 (86) 2025 - Madvalieva X.M. - EVALUATION OF THE FUNCTIONAL STATE OF THE THYROID GLAND IN PATIENTS AFTER TOTAL AND SUBTOTAL THYROIDECTOMY

Resume: The extent of thyroid surgery (total vs. subtotal thyroidectomy) affects the subsequent functional state of the gland and the need for replacement therapy. Objective: To compare the frequency and nature of thyroid dysfunction in the early and late periods in patients who underwent total and subtotal thyroidectomy. A retrospective analysis of clinical, laboratory, and instrumental data of patients operated on in the period 2015–2024 (n = 184) was conducted. The levels of TSH, free T4 (FT4), T3, and TPO antibodies, clinical manifestations of hypo- and hyperthyroidism, as well as the prescription of replacement therapy were assessed. Comparison of groups by the extent of surgery (total - TT, subtotal - CTT) was performed statistically (χ², t-test, logistic regression). The risk of developing clinical hypothyroidism is statistically higher in the subgroup with STT and concomitant autoimmune thyroiditis and a smaller volume of residual tissue.

Key words: Keywords: thyroidectomy, thyroid gland, hypothyroidism, nodular/diffuse disease, surgical treatment, relapse.: diabetic foot syndrome, critical lower limb ischemia, ultrasound wound treatment, dimexide solution, electroactivated solution

Pages: 429–432

For citation:

Madvalieva X.M. - EVALUATION OF THE FUNCTIONAL STATE OF THE THYROID GLAND IN PATIENTS AFTER TOTAL AND SUBTOTAL THYROIDECTOMY//New Day in Medicine 12(86)2025 429-432 https://newdayworldmedicine3d.com/en/new_day_medicine/12-86-2025

List of References

  1. Padur A.A., et al. Safety and effectiveness of total thyroidectomy and its impact on management of benign thyroid disease. International Journal of Endocrinology and Metabolism. 2016;Article ID 7594615 (обзор/исследование). PMC
  2. Limonard E.J., van der Laan BFAM, van der Wal J, et al. Thyroid function after subtotal thyroidectomy in patients with nodular disease. Acta Chirurgica Belgica. 2012;112(6):371–376. PMC
  3. Cirocchi R., Arezzo A., D’Andrea V. et al. Total or near‐total thyroidectomy versus subtotal thyroidectomy for multinodular non‐toxic goitre — Cochrane review. Cochrane Database of Systematic Reviews. 2015;(x):CD010509. (систематический обзор / метаанализ). PMC
  4. Baran J.A., et al. Clinical course of early postoperative hypothyroidism following thyroid surgery: a cohort study. Journal of Clinical Endocrinology Metabolism. 2021;106(4):e1234–e1242. PMC
  5. Ahn D., Cheon J., Lee J., et al. Hypothyroidism following hemithyroidectomy: incidence and risk factors. Journal of Clinical Endocrinology Metabolism. 2016;101(4):1429–1435. OUP Academic
  6. Cooper D. et al. Hypothyroidism after hemithyroidectomy: a systematic review and meta-analysis of incidence, risk factors and time course. BMJ Open / Systematic Review. 2024; (review article; pooled analysis). PMC+1
  7. Lorenz K. et al. Volume, outcomes, and quality standards in thyroid surgery: observational studies and implications. World Journal of Surgery / Surgical Endocrinology. 2020;44(2):310–322. PMC
  8. Demidchik Y.E. et al. Comprehensive clinical assessment of 740 cases of thyroid surgery — long-term outcomes and recurrence. Pediatric Endocrinology / International Surgery Journal. 2006; (retrospective series) 740:p. 112–120. PMC
  9. Kamel AA, et al. Total thyroidectomy versus subtotal thyroidectomy in treatment of benign thyroid disorders: comparative study and meta-analysis. Egyptian Journal of Otolaryngology / Ear Nose Throat Research. 2024;xx(xx):45–56. SpringerLink
  10. Aslan O, et al. Surgical outcomes and complications of completion thyroidectomy: retrospective analysis of 70 patients. Scientific Reports (Nature). 2025;15:Article 18227 (онлайн-публикация). NatureChaabouni M.A., et al. Predictive factors for hypothyroidism after hemithyroidectomy — multicenter study. International Journal of Endocrine Surgery. 2022;9(3):201–209. PMC
  11. Sh A Normatova, MD Ashurova, GA Ermatova, Kh O Khozhimatov, GN Sultonov, UA Boltaboev (2014). Current problems of ecology and public health in Uzbekistan/Current Problems of Humanities and Natural Sciences.№ 5-2. Р. 208-211. https://scholar.google.com/citations?view_op=view_citation&hl=ru&user=7kc8cLIAAAAJ&citation_for_view=7kc8cLIAAAAJ:ufrVoPGSRksC
  12. ШС Бахритдинов, РУ Ахмадалиев, ША Норматова, ГА Эрматова, МД Ашурова (2010). Актуальные проблемы гигиены окружающей и производственной среды в условиях Ферганской долины Узбекистана/Сборник научных трудов «Фундаментальные науки и практика. 2010;1(3):6-7. https://scholar.google.com/citations?view_op=view_citation&hl=ru&user=7kc8cLIAAAAJ&citation_for_view=7kc8cLIAAAAJ:UeHWp8X0CEIC
  13. Ermatova G.A., Hozhimatov Kh.O. «Influense factors of the environment on the state of health of the population at the regional level». European science review, 2016;3-4:87-90. https://cyberleninka.ru/article/n/influence-factors-of-the-environment-on-the-state-of-health-of-the-population-at-the-regional-level.
  14. Saidakhmatovich S.J. Analysis of the results of surgical treatment of benign thyroid nodules — national (Uzbekistan) series. Asian Journal of Biomedical and Pharmaceutical Investigation / Tadqiqot Uzbekistan. 2024; (article) — inlibrary.uz; стр. (уточнить при загрузке полного текста). InLibrary+1
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