158 -12 (86) 2025 - Dehqonov Q.A. - DYNAMIC MORPHOFUNCTIONAL CHANGES IN CELL MEMBRANES IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS BEFORE AND AFTER INTERACTIVE CORRECTION IN THE EXPERIMENT

Resume: The problem of urolithiasis and urinary tract infection in childhood, especially in hot climate regions, continues to be the focus of pediatric urology. Purpose of the research: To study morphofunctional disorders of cell membranes in urolithiasis complicated by obstructive pyelonephritis, and complex correction of the metabolic process in the experiment. Material and methods: Experimental studies were carried out on 65 (5-6 months old) male rabbits of the "chinchilla" breed, weighing 3000-3500 g. All animals were divided into 2 groups: group 1, EOP, against the background of traditional treatment - 30 rabbits; Group 2, EOP, against the background of metabolic treatment - 35 rabbits. Results and discussion: In experimental animals, on day 15 without treatment, glomeruli plethora is observed, the epithelium of the proximal and distal tubules is flattened, and the brush border is reduced in places. In 3 months after metabolic therapy in animals, the structure is mosaic, along with destructively altered areas, they are revealed with a normal structure. In 6 months after the start of metabolic treatment, the main part of the renal tissue has a normal structure, areas with destructively altered nephron tubules are relatively less often visible, and sclerosis is almost not detected.

Key words: Key words: morphofunctional disorders of cell membranes in urolithiasis, complicated obstructive pyelonephritis, experimental studies

Pages: 899–905

For citation:

Dehqonov Q.A. - DYNAMIC MORPHOFUNCTIONAL CHANGES IN CELL MEMBRANES IN UROLITHIASIS COMPLICATED BY OBSTRUCTIVE PYELONEPHRITIS BEFORE AND AFTER INTERACTIVE CORRECTION IN THE EXPERIMENT//New Day in Medicine 12(86)2025 899-905 https://newdayworldmedicine3d.com/en/new_day_medicine/12-86-2025

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