62 -1 (87) 2026 - Ro`ziqulova F.U., Yariyev A.A. - PHYSIOLOGICAL ASSESSMENT OF THE ACUTE STRESS RESPONSE IN RATS WITH ANALYSIS OF ADRENALINE LEVELS AND BODY WEIGHT DYNAMICS
- Ro`ziqulova F.U. - Termez Branch of Tashkent State Medical University, Republican Scientific Center for Emergency Medical Care, Syrdarya Branch, Gulistan
- Yariyev A.A. - Termez Branch of Tashkent State Medical University, Republican Scientific Center for Emergency Medical Care, Syrdarya Branch, Gulistan
- Axmedov K.H. - Termez Branch of Tashkent State Medical University, Republican Scientific Center for Emergency Medical Care, Syrdarya Branch, Gulistan
Resume: This experimental study evaluated physiological responses to acute stress in rats using a forced swim model. Thirty rats were divided into control and stress groups. Adrenaline levels and body weight were assessed on day four of exposure. Stressed animals showed a significant increase in plasma adrenaline and a decrease in body weight compared to controls, indicating activation of the sympatho-adrenal system and metabolic shifts. The model proved effective for studying acute stress-related neuroendocrine and metabolic responses.
Key words: Keywords: General Adaptation Syndrome, acute stress, experimental study, body weight, adrenaline.
Pages: 367–370
For citation:
Ro`ziqulova F.U., Yariyev A.A., Axmedov K.H. - PHYSIOLOGICAL ASSESSMENT OF THE ACUTE STRESS RESPONSE IN RATS WITH ANALYSIS OF ADRENALINE LEVELS AND BODY WEIGHT DYNAMICS//New Day in Medicine 1(87)2026 367-370 https://newdayworldmedicine3d.com/en/new_day_medicine/1-87-2026
List of References
- Руководство по экспериментальному (доклиническому) изучению новых фармакологических веществ / [под общ. ред. Р. У. Хабриева]. – 2-е изд., перераб. и доп. – М.: ОАО Изд-во «Медицина», 2005. – 832 с.
- Руководство по проведению доклинических исследований лекарственных средств. Часть первая / [под ред. А.Н. Миронова]. – М.: Гриф и К, 2012. – 944 с.
- Alam MJ, et al. Prevalence and level of stress among final-year students at a health science institute in Bangladesh. 2025. (≈68.6 % студентов испытывали стресс)
- Bezie AE, et al. Prevalence of stress and associated factors among students. Front Public Health. 2025 (≈37–40 % стресс-симптомов у студентов)
- Dülger H., et al. Prevalence of stress, anxiety, depression and sleep issues. PMC. 2025 (≈39 % стресс)
- Roth RR. General adaptation syndrome (GAS). EBSCOhost Research Starters. 2025 (объяснение GAS модели и её значимости)
- Rosas-Sánchez, G. U., German-Ponciano, L. J., Rodríguez-Landa, J. F. (2022). Considerations of pool dimensions in the forced swim test in predicting the potential antidepressant activity of drugs. Frontiers in Behavioral Neuroscience, 15, 757348. https://doi.org/10.3389/fnbeh.2021.757348
- Sokal, R. R., Rohlf, F. J. (2012). Biometry: The Principles and Practice of Statistics in Biological Research (4th ed.). W. H. Freeman.
- Tshomo T., et al. Prevalence and factors associated with workplace stress. 2025 (48.2 % с рабочим стрессом)
- Yang, L., Xu, B., Yuan, C., Dai, Z., Wang, Y., Li, Q., Yang, Q., Li, N., Qing, H. (2019). The antioxidative action of ZTP by increasing Nrf2/ARE signal pathway. Evidence-Based Complementary and Alternative Medicine, 2019, Article 5421528